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American Society of Microbiology ABMM Sample Questions (Q135-Q140):
NEW QUESTION # 135
A foodborne outbreak is suspected after several individuals who attended a potluck dinner develop nausea, vomiting, and abdominal cramps within 1-6 hours of eating. No fever or diarrhea is reported. The MOST likely bacterial toxin involved is:
- A. Staphylococcal enterotoxin
- B. Clostridium perfringens enterotoxin
- C. Shiga toxin
- D. Botulinum toxin
Answer: A
NEW QUESTION # 136
A clinical microbiology laboratory is implementing a new real-time PCR assay for the direct detection of Chlamydia trachomatis in urine samples. To ensure the accuracy of negative results, it is essential to include:
- A. An internal amplification control to detect PCR inhibition.
- B. A high concentration of the Chlamydia trachomatis target sequence.
- C. A melting curve analysis to confirm the specificity of the amplicon.
- D. A positive control containing Neisseria gonorrhoeae DNA.
Answer: A
NEW QUESTION # 137
Clavulanic acid is often combined with amoxicillin (e.g., Augmentin™) to overcome certain types of bacterial resistance. What is the primary mechanism by which clavulanic acid enhances amoxicillin's activity?
- A. It inhibits bacterial efflux pumps that would otherwise remove amoxicillin from the cell.
- B. It increases the outer membrane permeability to amoxicillin in Gram-negative bacteria.
- C. It binds to alternative penicillin-binding proteins (PBPs), providing a synergistic bactericidal effect.
- D. It functions as a potent, irreversible inhibitor of many bacterial beta-lactamase enzymes.
Answer: D
NEW QUESTION # 138
According to the current CDC-recommended laboratory algorithm for diagnosing HIV infection in adults and children aged >18 months, what is the recommended initial screening test?
- A. HIV-1/HIV-2 antigen/antibody combination immunoassay
- B. HIV-1/HIV-2 antibody differentiation immunoassay
- C. HIV-1 p24 antigen assay only
- D. HIV RNA nucleic acid test (NAT)
Answer: A
NEW QUESTION # 139
A microbiology laboratory is investigating an outbreak of bloodstream infections in a neonatal intensive care unit. Isolates of Staphylococcus epidermidis from multiple infants show indistinguishable banding patterns by pulsed-field gel electrophoresis (PFGE). This finding MOST strongly suggests:
- A. Recent horizontal gene transfer of virulence factors.
- B. A common source of infection and clonal spread of the organism.
- C. Widespread antibiotic resistance within the S. epidermidis population.
- D. Spontaneous mutations leading to increased pathogenicity.
Answer: B
NEW QUESTION # 140
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